Location: Greater Boston Area (On-site, 5 days/week)
The Opportunity
A rapidly growing, clinical-stage biotech company is hiring a Sr. Scientist to support Analytical Development and Quality Control for their peptide-based therapeutic programs. This is a highly hands-on, management role for someone who can own and execute HPLC/UPLC, validation and method development based testing.
This position will play a key role in ensuring analytical readiness as programs advance through Phase 1 → Phase 2 and beyond.
What You’ll Own
- Lead and execute HPLC/UPLC analytical methods supporting in-process, release, and stability testing
- Drive chromatography workstreams including SEC and reverse-phase methods (primary focus)
- Serve as the technical “go-to” for method troubleshooting, system performance issues, and investigation support
- Support and/or lead method qualification and validation activities in a GMP-aligned environment
- Provide oversight for routine QC testing, data review, and documentation practices
- Write and maintain key technical documentation including SOPs, protocols, reports, and audit-ready records
- Partner cross-functionally with teams spanning development, manufacturing, and quality
- Mentor and guide junior scientists / associates while remaining highly hands-on in the lab
What We Looking For
- Ph.D. in Analytical Chemistry, Biochemistry, or related field with a minimum of 4 years
- Deep, practical experience with HPLC + UPLC
- Strong chromatography foundation (especially SEC + RP)
- Background in a GMP environment with direct exposure to method qualification/validation
- Proven ability to troubleshoot and resolve real lab problems quickly (not just run methods)
- Comfortable leading from the bench and supporting a growing team
Preferred Background
- Experience working with peptides or complex therapeutic modalities
- Experience from environments like CDMOs/CMOs or high-throughput GMP labs
- Exposure to early clinical-stage programs (Phase 1/2)
Why This Role
- High visibility on a growing team
- Opportunity to impact analytical strategy and QC execution during a critical scale-up period
- Strong cross-functional exposure in a fast-moving environment
